Stress, itch, and scratch
نویسندگان
چکیده
منابع مشابه
Interneurons Scratch an Itch
Itch is immensely frustrating. Most studies focus on the cause of itch. In this issue of Neuron, Kardon et al. (2014) find that itch can be modulated by inhibitory neurons that produce dynorphin, an endogenous agonist of κ-opioid receptors.
متن کاملA new itch to scratch for TSLP.
Atopic dermatitis (AD) is characterized by allergic inflammation and itch. Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine implicated in AD. A paper in Cell transforms the understanding of the functional repertoire of TSLP in general and in AD in particular showing that TSLP can directly stimulate sensory neurons and provoke itch.
متن کاملPruritus: an overview. What drives people to scratch an itch?
Pruritus is a common complaint associated with many conditions. It negatively impacts sleep, quality of life, and mortality. Itch is transmitted along both histaminergic and non-histaminergic pathways with a complex interplay between keratinocytes, immune cells and cutaneous neurons. Individuals who present with pruritus should undergo a thorough assessment, especially those over 65 years old, ...
متن کاملItch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans.
Intense itch and urge to scratch are the major symptoms of many chronic skin ailments, which are increasingly common. Vicious itch-scratch cycles are readily established and may diminish quality of life for those afflicted. We investigated peripheral and central processing of two types of itch sensation elicited by skin-prick tests of histamine and allergen solutions. Itch-related skin blood fl...
متن کاملAre subjective accounts of itch to be relied on? The lack of relation between visual analogue itch scores and actigraphic measures of scratch.
There is a widespread belief that subjective accounts of disease are key components of measures of disease severity and quality of life. In the present study we have set out to test this hypothesis using visual analogue scales (VAS) for itch, as a subjective measure, and actigraphy as an objective measure. One-hundred and seventeen itchy children and adults (and 25 controls) were studied for cl...
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ژورنال
عنوان ژورنال: British Journal of Dermatology
سال: 2019
ISSN: 0007-0963,1365-2133
DOI: 10.1111/bjd.17651